Question 1

Which of the following statements regarding the cell cycle is TRUE?

Accepted Answer

A)  It has many major cell cycle checkpoints.
B)  It is regulated by cyclins and CDKs.
C)  Different levels of cyclins are observed at different cell cycle stages.
D)  It can be "paused" by the action of p53.
E)  All of these choices are correct.F) C) and D)
G) All of the above

Question 2

Cell division is regulated by:

Accepted Answer

A)  growth factor signals.
B)  signals that indicate that the cell has reached a sufficient size.
C)  signals that indicate that DNA has been replicated.
D)  signals about the nutritional status of the cell.
E)  All of these choices are correct.F) A) and B)
G) C) and D)

Question 3

Sister chromatids are separated during:

Accepted Answer

A)  mitosis.
B)  meiosis I and mitosis.
C)  meiosis II and mitosis.
D)  meiosis I.
E)  meiosis II.F) B) and C)
G) C) and E)

Question 4

The assembly of what cytoskeletal protein is initiated by the M cyclin-CDK complex?

Accepted Answer

A)  microfilaments
B)  microtubules
C)  intermediate filaments
D)  All of these choices are correct.E) A) and C)
F) A) and B)

Question 5

During meiosis, two rounds of DNA synthesis are required to form four gametes from one parent cell.

Accepted Answer

A) True 
 B)False

Question 6

Which one of the following is capable of phosphorylating key proteins involved in regulating the cell cycle?

Accepted Answer

A)  cyclin
B)  CDK
C)  phosphatase
D)  p53 protein
E)  cyclin-CDK complexF) All of the above
G) None of the above

Question 7

Processes that regulate cell division in mammals include:

Accepted Answer

A)  production of cyclin proteins that activate CDK enzymes.
B)  activated cyclin-CDK complexes triggering cell cycle events.
C)  different cyclins and CDKs acting at different stages of the cell cycle to promote cell division.
D)  rapid degradation of cyclins after CDK activation.
E)  All of these choices are correct.F) A) and E)
G) B) and C)

Question 8

A researcher is evaluating the expression of p53 in cells she is culturing in the laboratory. She notices that in a small group of cells, high levels of phosphorylated p53 occur in the nuclei. What can she deduce about these cells?

Accepted Answer

A)  These cells are normal.
B)  Within these cells, the cell cycle has been halted at the G2/M transition.
C)  These cells likely contain damaged DNA.
D)  All of these cells have entered meiosis.
E)  All of these cells have entered mitosis.F) A) and B)
G) None of the above

Question 9

In a normal cell, tumor suppressors are responsible for:

Accepted Answer

A)  increasing the rate of cell division.
B)  allowing the cell to correct replication errors.
C)  signaling that highly defective cells be destroyed.
D)  signaling that DNA replication is to begin.E) A) and C)
F) B) and D)

Question 10

In which phase of mitosis do chromosomes condense?

Accepted Answer

A)  prophase
B)  metaphase
C)  anaphase
D)  telophaseE) B) and D)
F) None of the above

Question 11

How must spindle microtubules attach to chromosomes during prometaphase of meiosis I?

Accepted Answer

A)  Spindle microtubules from one pole must attach to both kinetochores in a pair of sister chromatids.
B)  Spindle microtubules from one pole attach to one kinetochore, and spindle microtubules from the other pole attach to the other kinetochore in a pair of sister chromatids, just like in mitosis.
C)  Microtubules attach to the chiasma.
D)  Microtubules attach using their minus (slow assembling) ends.
E)  Microtubules attach at the centrosomes.F) All of the above
G) A) and B)

Question 12

The second meiotic division resembles mitosis because:

Accepted Answer

A)  sister chromatids are separated during anaphase II to become the chromosomes of the daughter cells.
B)  spindle microtubules attach from opposite directions to the centromere of each sister chromatid pair.
C)  chromosomes decondense during telophase II.
D)  the daughter cells have the same number of chromosomes as the parent cell..
E)  All of these choices are correct.F) A) and B)
G) A) and C)

Question 13

The process of cell division in a prokaryotic cell is called:

Accepted Answer

A)  binary fusion.
B)  mitosis.
C)  binary fission.
D)  cytokinesis.E) C) and D)
F) None of the above

Question 14

The division of the cell's cytoplasm in a eukaryotic cell is known as:

Accepted Answer

A)  cytokinesis.
B)  cell fission.
C)  mitosis.
D)  both cytokinesis and mitosis..E) B) and C)
F) A) and D)

Question 15

Several years ago, a man noticed a small mole on his wrist. Years later, the mole grew in size and the man was diagnosed as having metastatic melanoma. This was likely the result of:

Accepted Answer

A)  a single mutation affecting one proto-oncogene in a cell.
B)  a single mutation inactivating a tumor suppressor gene.
C)  several mutations affecting proto-oncogenes and/or tumor suppressor genes.
D)  None of the other answer options is correctcancers arise spontaneously, independent of mutations.E) B) and D)
F) A) and D)

Question 16

Which of these events does NOT include a checkpoint in the cell cycle?

Accepted Answer

A)  the transition from G1 to S phase
B)  the transition from G2 to M phase
C)  the beginning of M phase
D)  All of these events include a checkpoint in the cell cycle.E) All of the above
F) A) and B)

Question 17

Sister chromatids are BEST described as two DNA molecules that have:

Accepted Answer

A)  the same genes in the same order but having different alleles.
B)  the same alleles of the same genes in a different order.
C)  different genes in the same order and possibly having different alleles of some genes.
D)  different alleles of the same genes arranged in a different order.
E)  virtually identical sequences of nucleotides.F) A) and B)
G) None of the above

Question 18

What protein forms the contractile ring during cytokinesis in animal cells?

Accepted Answer

A)  kinesin
B)  actin
C)  dynein
D)  DNA polymeraseE) A) and B)
F) A) and C)

Question 19

The development of cancer requires both the _____ of an oncogene and the _____ of a tumor suppressor.

Accepted Answer

A)  activation; activation
B)  activation; inhibition
C)  inhibition; activation
D)  inhibition; inhibitionE) B) and C)
F) A) and C)

Question 20

The epithelial cells in the skin of an animal have 24 chromosomes. How many chromosomes are present in the gametes of this animal?

Accepted Answer

A)  6
B)  12
C)  24
D)  48E) A) and B)
F) A) and C)

Exam 11: Cell Division: Variations, Regulation, and Cancer

The epithelial cells in the skin of an animal have 24 chromosomes. How many chromosomes are present in the gametes of this animal?

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Cell division is regulated by:

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During meiosis, two rounds of DNA synthesis are required to form four gametes from one parent cell.

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The second meiotic division resembles mitosis because:

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Sister chromatids are separated during:

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The process of cell division in a prokaryotic cell is called:

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Processes that regulate cell division in mammals include:

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Sister chromatids are BEST described as two DNA molecules that have:

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Which one of the following is capable of phosphorylating key proteins involved in regulating the cell cycle?

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What protein forms the contractile ring during cytokinesis in animal cells?

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Several years ago, a man noticed a small mole on his wrist. Years later, the mole grew in size and the man was diagnosed as having metastatic melanoma. This was likely the result of:

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Which of the following statements regarding the cell cycle is TRUE?

Correct AnswerverifiedShow Answer

The development of cancer requires both the _____ of an oncogene and the _____ of a tumor suppressor.

Correct AnswerverifiedShow Answer

The assembly of what cytoskeletal protein is initiated by the M cyclin-CDK complex?

Correct AnswerverifiedShow Answer

How must spindle microtubules attach to chromosomes during prometaphase of meiosis I?

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In a normal cell, tumor suppressors are responsible for:

Correct AnswerverifiedShow Answer

The division of the cell's cytoplasm in a eukaryotic cell is known as:

Correct AnswerverifiedShow Answer

A researcher is evaluating the expression of p53 in cells she is culturing in the laboratory. She notices that in a small group of cells, high levels of phosphorylated p53 occur in the nuclei. What can she deduce about these cells?

Correct AnswerverifiedShow Answer

Which of these events does NOT include a checkpoint in the cell cycle?

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In which phase of mitosis do chromosomes condense?

Correct AnswerverifiedShow Answer

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The development of cancer requires both the _ of an oncogene and the _ of a tumor suppressor.

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