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A chemical is called a(n) ____ when it flows through the blood to targets throughout the body.


A) hormone
B) neurotransmitter
C) neuromodulator
D) endocrine

E) All of the above
F) C) and D)

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Which of the following is TRUE about EPSPs?


A) It takes two to produce an action potential.
B) They decay over time and space.
C) They can be either excitatory or inhibitory.
D) They occur because potassium gates open.

E) C) and D)
F) All of the above

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In a reflex arc, the coordination between contraction of certain muscles and relaxation of others is mediated by:


A) glial cells.
B) motor neurons.
C) sensory neurons.
D) interneurons.

E) A) and B)
F) B) and D)

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Activation of autoreceptors tends to:


A) increase further neurotransmitter release.
B) stimulate GABA release.
C) increase sodium-potassium pump activity.
D) decrease further neurotransmitter release.

E) B) and C)
F) B) and D)

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The research that firmly established synaptic communication as chemical was:


A) Elliot's adrenaline mimicking sympathetic activation.
B) Loewi's transfer of fluid from stimulated frog hearts.
C) Sherrington's study of reflexes.
D) Eccles's measurement of IPSPs.

E) B) and C)
F) None of the above

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If a drug has high affinity and low efficacy, what effect does it have on the postsynaptic neuron?


A) antagonistic
B) agonistic
C) proactive
D) destructive

E) B) and D)
F) B) and C)

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The "decision" for a neuron to fire is determined by the:


A) number of EPSPs only.
B) spontaneous firing rate.
C) number of IPSPs only.
D) ratio of EPSPs to IPSPs.

E) A) and B)
F) B) and D)

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Whether or not a neurotransmitter is excitatory depends on the response of the postsynaptic receptor.

A) True
B) False

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Why are the withdrawal effects of marijuana usually less intense than other drugs?


A) Marijuana affects only the brain stem.
B) Marijuana leaves the body slowly.
C) Marijuana affects only presynaptic neurons.
D) The body compensates by producing more dopamine.

E) A) and C)
F) None of the above

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A drug that produces excitement, alertness, elevated mood, and decreased fatigue is referred to as a:


A) stimulant.
B) depressant.
C) hallucinogen.
D) tranquilizer.

E) B) and C)
F) C) and D)

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Most neurons release more than one kind of neurotransmitter.

A) True
B) False

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Suppose a new neurotransmitter is identified that does not excite or inhibit postsynaptic cells, but affects the release of other neurotransmitters or the sensitivity of postsynaptic cells. This neurotransmitter would most likely be categorized as a(n) :


A) neuromodulator.
B) ionotropic modulator.
C) hormone.
D) gas.

E) A) and B)
F) A) and C)

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Receptor molecules for neurotransmitters that exert metabotropic effects are proteins that bind to ____ outside the membrane, and attach to ____ inside the membrane.


A) calcium; potassium
B) neurotransmitters; nicotine
C) neurotransmitters; G-proteins
D) adenosine; nitric oxide

E) B) and D)
F) B) and C)

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The catecholamines include:


A) epinephrine, norepinephrine, dopamine, and serotonin.
B) epinephrine, serotonin, and dopamine.
C) dopamine, serotonin, and acetylcholine.
D) epinephrine, norepinephrine, and dopamine.

E) C) and D)
F) B) and C)

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Which one of Sherrington's inferences about the synapse was WRONG?


A) Transmission at a synapse is slower than transmission of impulses along an axon.
B) Transmission at the synapse is primarily an electrical process.
C) Synapses can be either excitatory or inhibitory.
D) Synapses make spatial summation and temporal summation possible.

E) A) and B)
F) A) and C)

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Reflexive flexion and extension of a dog's legs can still occur when the spinal cord is disconnected from the brain.

A) True
B) False

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A new drug is discovered that affects the activity of enzymes. Which of the following stages of synaptic transmission is most likely to be affected?


A) Synthesis
B) Diffusion
C) action potential
D) Release

E) A) and D)
F) A) and C)

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At the synapse, cocaine:


A) increases the synthesis of dopamine.
B) blocks the breakdown of dopamine.
C) accelerates the breakdown of dopamine.
D) blocks the reuptake of dopamine.

E) A) and C)
F) All of the above

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A reflex arc consists only of sensory neurons.

A) True
B) False

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Insulin increases the entry of tryptophan into the brain by:


A) weakening the blood-brain barrier.
B) converting tryptophan into a compound that more easily enters the brain.
C) increasing metabolic activity only in those areas of the brain that use tryptophan.
D) causing certain competing amino acids to enter other cells, outside the brain.

E) A) and B)
F) A) and C)

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